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Systemic sclerosis is a rare chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities in the skin, joints, and internal. Scleroderma is a disease of the body's connective tissue. Scleroderma means 'hard skin'. The most common symptom is a thickening and hardening of the skin. In contrast, diffuse scleroderma, also known as systemic scleroderma, affects many parts of the body. This is the more serious form of the condition. Without.

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Diffuse scleroderma is the other form of systemic scleroderma. In diffuse scleroderma, people experience thickening of the skin of the arms, legs, face, chest. Other symptoms of systemic scleroderma include joint pain and stiffness, pain and stiffness in the muscles, shortness of breath, fatigue, indigestion or. Early on, the disease can be diagnosed as rheumatoid arthritis or lupus. Antinuclear antibody (ANA) is present in approximately 95% of patients with.

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Scleroderma is a disease of the body's connective tissue. Scleroderma means 'hard skin'. The most common symptom is a thickening and hardening of the skin. In contrast, diffuse scleroderma, also known as systemic scleroderma, affects many parts of the body. This is the more serious form of the condition. Without. The prognosis is severe (year survival rate of %) because of the high risk of life-threatening complications: renal crisis, severe digestive involvement.